4-Hydroxyphenylboronic acid, identified by CAS 71597-85-8, is an aromatic boronic acid containing both a boronic acid group and a para-hydroxyl group on a benzene ring. Its molecular formula is C6H7BO3, and its commonly reported molecular weight is 137.93 g/mol. I supply this compound as a research and synthesis intermediate for applications including palladium-catalyzed Suzuki coupling, pharmaceutical intermediate development, agrochemical research, and boron-containing functional molecule design.
The compound is also known as 4-boronophenol or 4-hydroxybenzeneboronic acid. Its two functional groups create complementary reactivity: the aryl boronic acid group participates in carbon–carbon bond formation, while the phenolic hydroxyl group can support further derivatization or molecular recognition. Because commercial requirements vary by application, I recommend confirming identity, assay, water content, packaging, and analytical documentation before placing a production order.
The boronic acid group is the principal synthetic handle in this molecule. In Suzuki–Miyaura coupling, an aryl boronic acid can react with an aryl or vinyl halide in the presence of a suitable palladium catalyst and base to form a new carbon–carbon bond. The exact yield and selectivity depend on the reaction substrate, catalyst system, solvent, temperature, base, and work-up procedure, so I do not treat the compound as a guaranteed solution for every coupling process.
The boronic acid group can also participate in reversible interactions with diols and related oxygen-containing structures under appropriate conditions. This characteristic makes 4-hydroxyphenylboronic acid relevant to molecular recognition, sensor development, and probe synthesis. However, the suitability of the material for these applications should be assessed using the customer’s target structure, pH range, solvent system, and required detection performance.
The para-hydroxyl group gives the molecule a second point of chemical differentiation. It may be used in downstream etherification, esterification, crosslinking, or other functionalization strategies, depending on the selected reagents and protection strategy. In some synthesis routes, the phenolic group may need protection to control chemoselectivity, while in other routes it is intentionally retained for biological or material-property studies.
As an aromatic organic solid, the compound should be handled according to the applicable safety data sheet and the customer’s laboratory or plant procedures. I recommend minimizing exposure to heat, incompatible oxidizing conditions, and unnecessary moisture during storage and processing. A buyer should verify the supplier’s recommended storage conditions because packaging, product age, and local handling requirements can influence the practical shelf-life strategy.
4-Hydroxyphenylboronic acid is used as a building block in the preparation of substituted biaryl and heteroaryl compounds. Medicinal chemistry teams may use it to introduce a para-hydroxyphenyl fragment into a lead structure through a coupling step. The resulting intermediate may then undergo additional transformations, purification, and analytical evaluation.
The compound can serve as an aryl-boron reagent in the development of fine chemicals and agricultural research intermediates. Its value is greatest when the target route benefits from modular carbon–carbon bond formation and when the phenolic group provides a useful downstream functionalization site. Route developers should evaluate catalyst compatibility and the effect of the phenolic group on solubility and reaction selectivity.
Researchers may also investigate this compound in boron-containing polymers, fluorescent probes, recognition systems, and responsive materials. The boronic acid and phenolic groups can contribute different bonding or derivatization options in a designed molecular architecture. These uses are project-specific, and performance should be confirmed through the customer’s own formulation, spectroscopy, stability, and application testing.
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For procurement purposes, “4-hydroxyphenylboronic acid” may refer to the same core chemical identity while the commercial specification differs. Buyers may request research grade, higher-assay material, or a custom quality profile depending on whether the compound is used for route scouting, process development, analytical standards, or manufacturing. I encourage customers to define the intended use before comparing quotations.
| Material consideration | Why it matters |
|---|---|
| Assay or purity | Influences stoichiometric accuracy, impurity control, and downstream purification requirements. |
| Water content | May affect weighing, reaction concentration, and reproducibility in moisture-sensitive procedures. |
| Particle and packaging format | Can influence sampling, dissolution, handling, and storage efficiency. |
| Analytical documentation | Supports identity confirmation and batch-to-batch quality review. |
A practical specification review should begin with the fixed identity data: CAS 71597-85-8, formula C6H7BO3, and molecular weight 137.93 g/mol. I then recommend confirming the requested assay limit, appearance, identification method, water content, residual solvents, and any elemental or inorganic impurity requirements. These limits should be agreed in writing rather than inferred from a general catalog description.
Typical analytical documents may include a certificate of analysis, chromatographic purity result, spectroscopy data, and batch or lot information, subject to the product grade and order arrangement. I avoid presenting a single universal purity value because commercial specifications can differ by manufacturing route and customer requirement. If the material will enter a regulated or quality-controlled process, the buyer should also review document format, change-notification expectations, and sample approval procedures.
The lowest unit price is not always the lowest total procurement cost. Buyers should compare assay, usable yield, packaging loss, documentation, minimum order quantity, lead time, and the supplier’s ability to maintain consistent specifications. For a process development project, a smaller evaluation pack may reduce risk; for routine production, a stable batch plan and agreed release criteria may be more important.
Lead time should be confirmed for the requested quantity rather than copied from a general product listing. I also recommend asking whether the quoted material is available from stock, scheduled for production, or subject to raw-material confirmation. This distinction helps purchasing teams plan experiments and prevents avoidable delays when a project moves from gram-scale research to larger synthesis campaigns.
At Maison Chemical, I support customers evaluating 4-Hydroxyphenylboronic acid CAS 71597-85-8 for laboratory research, process development, and commercial chemical sourcing. I can help align the requested grade with the intended application, review target specifications, and discuss available packaging or supply quantities. Where a standard specification does not fit the project, I recommend sharing the customer’s technical requirements before quotation.
My support approach focuses on clear communication of product identity, quality documentation, packaging, logistics, and commercial terms. Customers may request a specification review, sample discussion, or batch documentation assessment before committing to a larger order. Actual availability, minimum order quantity, lead time, and pricing should be confirmed for each inquiry because they depend on quantity, destination, packaging, and quality requirements.
4-Hydroxyphenylboronic acid CAS 71597-85-8 is a useful bifunctional building block when a synthesis requires an aryl boronic acid together with a para-hydroxyl group. It is particularly relevant to cross-coupling chemistry, pharmaceutical and agrochemical intermediate development, and functional molecule research. Its practical suitability depends on the target route, reaction conditions, required quality level, and downstream purification strategy.
As the next step, I recommend defining your target quantity, assay requirement, analytical documentation, packaging format, and delivery destination. Share these details with Maison Chemical so I can help evaluate the appropriate supply option and provide a quotation based on your actual B2B requirements. This approach gives your technical and purchasing teams a clearer basis for sample approval, production planning, and repeat sourcing.
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