1,4-Cyclohexanedione monoethylene acetal, identified by CAS 4746-97-8, is a protected cyclohexanone building block used mainly in organic synthesis and pharmaceutical intermediate development. Its commonly reported molecular formula is C8H10O3, with a molecular weight of approximately 154.16 g/mol. I recommend evaluating this material by chemical identity, assay, water content, impurity profile, packaging, documentation, and supply consistency rather than by price alone.
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The compound contains one ketone group and one ethylene ketal-protected ketone within a cyclohexane framework. This combination gives chemists a practical way to carry one carbonyl function through selected reaction steps while retaining another carbonyl for later transformation. Because appearance, purity, storage stability, and commercial specifications can vary by supplier and lot, buyers should request a current specification sheet and certificate of analysis before placing a production order.
This guide is intended for procurement teams, process chemists, pharmaceutical intermediate manufacturers, contract development and manufacturing organizations, and distributors sourcing CAS 4746-97-8. It is also useful for research groups that need a protected dicarbonyl-derived intermediate for route screening or scale-up assessment. I focus here on practical buying decisions and documented product evaluation rather than making unsupported claims about a specific reaction yield or end-use product.
Ketals are commonly used as protecting groups for carbonyl compounds. In 1,4-cyclohexanedione monoethylene acetal, the ethylene acetal masks one ketone, while the remaining ketone stays available for reactions such as condensation, reduction, oxidation, or carbon–carbon bond formation, depending on the selected process conditions. The protected carbonyl can potentially be revealed later under suitable deprotection conditions.
This selective reactivity is the principal reason buyers consider this material. It can help reduce unwanted reactions between two carbonyl groups and may simplify the sequence design of an intermediate synthesis. The suitability of the compound still depends on reaction conditions, solvent compatibility, acid sensitivity, downstream purification, and the required impurity limits.
For initial identification, the key data commonly associated with CAS 4746-97-8 include a molecular weight of approximately 154.16 g/mol and the molecular formula C8H10O3. The product is generally handled as an organic solid or crystalline material, but the exact appearance and physical form should be confirmed against the supplier’s current batch specification. Melting behavior, color, and physical state may be influenced by purity, residual solvent, and storage history.
| Evaluation item | Why it matters | Buyer action |
|---|---|---|
| CAS number and chemical name | Confirms the intended substance and reduces identity errors | Check the CAS number against the quotation, label, SDS, and COA |
| Assay or purity | Influences reaction performance and impurity burden | Request the stated analytical method and lot-specific result |
| Water and residual solvents | May affect sensitive reactions and process reproducibility | Define limits according to the planned synthesis |
| Appearance and physical form | Supports receiving inspection and handling decisions | Confirm expected color, form, and packaging conditions |
| Packaging and storage | Helps protect material quality during transport and warehousing | Review container type, closure, labeling, and recommended storage |
I advise buyers not to treat a single numerical purity value as the complete quality profile. A high assay result may not answer questions about water, residual solvents, regioisomeric impurities, or process-specific contaminants. For regulated or technically sensitive projects, the purchasing specification should identify the critical quality attributes and the analytical methods used to measure them.
CAS 4746-97-8 may be used as a synthetic intermediate or building block in the preparation of more complex pharmaceutical and fine chemical structures. Its value comes from the combination of a reactive ketone and a selectively protected carbonyl. The actual suitability for a pharmaceutical route must be demonstrated through route-specific development work, including impurity tracking and compatibility studies.
In research and process development, the compound can be considered when a chemist needs differentiated carbonyl reactivity in a cyclic substrate. It may support exploratory transformations before a process is optimized for solvent, temperature, reagent loading, work-up, and purification. I recommend purchasing a small evaluation quantity first when the reaction has not yet been validated at the intended scale.
Manufacturers may also use this material in custom synthesis programs where a protected ketone is incorporated into an intermediate sequence. In such cases, the buyer should discuss not only product availability but also batch-to-batch consistency, analytical support, and the supplier’s ability to maintain the same specification over repeat orders. A material that works in a small laboratory experiment may require additional controls before commercial process adoption.
Commercial options are usually differentiated by intended use, purity requirement, packaging size, and documentation level rather than by fundamentally different chemical structures. Research quantities may be suitable for screening, while process-grade material may require tighter limits for assay, water, residual solvents, particle characteristics, and trace impurities. Buyers should avoid assuming that a product labeled “high purity” automatically meets pharmaceutical development or manufacturing requirements.
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Some projects may require a standard product specification, while others may need a customized control strategy. Relevant options can include different pack sizes, reinforced export packaging, lot-specific analytical documentation, and pre-shipment sample approval. The correct choice depends on the process stage, expected consumption, regulatory environment, and cost of a failed batch.
Before requesting quotations, I recommend documenting the intended reaction, approximate annual or project demand, required assay, acceptable water level, prohibited impurities, packaging preference, and destination country. Also clarify whether the material is for laboratory research, process development, validation, or routine production. This information helps suppliers provide a more accurate and relevant quotation.
Ask each supplier for a current technical data sheet, safety data sheet, representative or lot-specific certificate of analysis, packaging information, and storage guidance. Compare the analytical method, not only the reported number, because different methods may produce results that are not directly equivalent. If the product is intended for a controlled manufacturing process, discuss change notification and repeat-batch documentation in advance.
Price, MOQ, lead time, payment terms, shipping route, and export documentation should be evaluated together. A lower unit price may not be advantageous if the MOQ creates excess inventory or if an uncertain lead time interrupts production planning. For international shipments, confirm the correct product classification, label requirements, outer packaging, and documents needed by the consignee.
For a new supplier, a sample evaluation can help confirm identity, handling behavior, reaction performance, and compatibility with the buyer’s analytical method. The sample should be linked to clear documentation and, where appropriate, the same or comparable specification proposed for commercial supply. Approval should be based on technical results and supply capability rather than on a quotation alone.
The commercial price of CAS 4746-97-8 can vary with purity target, order quantity, packaging, production schedule, analytical requirements, and destination. Because these variables change, I recommend requesting a dated quotation instead of relying on an old market reference. Buyers should also ask whether the quoted lead time applies to stocked material, scheduled production, or a custom batch.
MOQ is particularly important for less frequently used intermediates. A small research order, pilot-scale order, and recurring production order may require different packaging and commercial terms. To compare offers fairly, calculate the delivered cost per usable kilogram and include testing, freight, customs handling, storage, and potential disposal of excess inventory.
As Maison Chemical, we support B2B buyers evaluating 1,4-cyclohexanedione monoethylene acetal for research, intermediate synthesis, and process development. We can discuss product specifications, quantity requirements, packaging, documentation, and delivery planning based on the project’s technical needs. Our recommended approach is to review the intended application first, then align the quotation and quality documents with the buyer’s acceptance criteria.
1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 is best viewed as a functional synthesis intermediate that provides differentiated carbonyl reactivity through ketone protection. For a sound purchasing decision, first define the process requirement, then verify identity and analytical data, evaluate a representative sample when appropriate, and confirm the supplier’s ability to support repeat supply. This sequence reduces technical and sourcing risk without relying on unsupported performance promises.
If you are sourcing this compound, send Maison Chemical your target quantity, required specification, destination, packaging preference, and intended project stage. We can then prepare a practical B2B quotation and discuss the available documentation and supply plan. For production-oriented projects, early communication about assay, impurity limits, MOQ, and lead time is the most effective next step.
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