1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester, CAS 903550-26-5, is a protected pyrazole boronate used as a building block in organic synthesis. Its pyrazole ring carries a pinacol boronic ester group that can serve as a coupling handle, while the tetrahydropyranyl (THP) substituent is attached to the ring nitrogen. Researchers and process chemists may evaluate it when designing routes to substituted pyrazoles, but its suitability depends on the reaction plan and the material’s verified quality. At Maison Chemical, we help B2B buyers assess identity, specification needs, and supply options before placing an order.
The formula and molecular weight above are structure-derived reference information, not a batch-specific certificate of analysis. Buyers should confirm identity and measured results against the supplier’s current documentation for the lot being offered. The compound should not be assumed to have a particular purity, appearance, storage life, or regulatory status without supporting product-specific data.
Pyrazole is a five-membered aromatic ring containing two nitrogen atoms. In this compound, a tetrahydropyran-2-yl group is bonded to a ring nitrogen, making the nitrogen substituted rather than bearing a free N–H. This feature can affect the compound’s reactivity and how it behaves in a synthetic route. Chemists should consider whether the THP group is appropriate for their planned conditions and whether it must remain in the target intermediate or be removed later.
The boronic ester is attached at the pyrazole 5-position and provides a functional handle for further carbon–carbon bond formation. Boronic esters are commonly considered in palladium-catalyzed Suzuki–Miyaura coupling design, although performance depends on the substrate, coupling partner, catalyst, base, solvent, and reaction conditions. The presence of a Bpin group indicates a potential synthetic role; it does not guarantee conversion, selectivity, or compatibility in a particular process. Route developers should confirm those points experimentally at an appropriate scale.
This compound may be considered as an intermediate when a synthesis requires a pyrazole fragment that can be elaborated through its boronate position. A chemist could assess it for coupling with a suitable halide or other compatible electrophile to build a substituted pyrazole scaffold. Its N-substituent may also provide a way to manage pyrazole nitrogen reactivity during selected steps. The usefulness of that protection strategy is route-specific and should be assessed alongside the planned deprotection conditions.
Potential application areas include medicinal chemistry research, heterocycle synthesis, and development of pharmaceutical intermediates. These are broad research contexts, not claims that the compound is an approved drug ingredient or suitable for a particular therapeutic product. Buyers should confirm whether the material’s grade, analytical package, and traceability meet their project and quality-system requirements. For regulated or late-stage work, confirm requirements with the responsible quality and regulatory teams before procurement.
There is no single universal specification that applies to every buyer or use. A research laboratory may prioritize identity confirmation and an assay appropriate for screening, while a process-development team may also need limits for water, residual solvents, or specific impurities. The analytical method and acceptance criteria should be agreed in writing, especially when results will be used to compare lots or support a defined process. Ask for the available lot-specific documents rather than relying on a generic product description.
| Specification item | What to confirm | Buyer consideration |
|---|---|---|
| Identity | CAS number and available structural or spectroscopic confirmation | Check that the documentation corresponds to the offered lot. |
| Assay or purity | Reported result, test method, and acceptance criteria | For example, a buyer may request a minimum assay of 95.0% or 98.0%; these are negotiation examples, not a universal standard. |
| Water and impurities | Whether these are tested and how results are reported | Set limits only when they matter to the intended chemistry or process. |
| Handling and packaging | Recommended storage, container type, and handling information | Follow the supplier’s lot-specific guidance and applicable site procedures. |
| Documentation | Certificate of analysis and any other available technical documents | Confirm document availability before order confirmation if required for release. |
The numerical assay examples in the table are buyer-defined targets, not reported test results for CAS 903550-26-5. Likewise, do not assume a particular shelf life or storage temperature unless it is supported by the supplier’s documentation. If moisture or a specific impurity could affect your reaction, specify the relevant test and limit during the inquiry rather than treating it as an implicit product attribute.
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Start by identifying the intended use: initial reaction screening, route development, or a larger process evaluation. Define the amount required, the desired assay, and any impurity or documentation requirements that affect the next step. A small research evaluation and a process-development campaign may call for different packaging, sampling, and release expectations. Sharing these requirements early helps a supplier assess whether the offered material and documentation are a practical fit.
Confirm that the quotation identifies the compound by both its name and CAS number. Request the current lot’s certificate of analysis and review the reported test methods, results, and dates where provided. If your project requires additional information—such as a particular impurity profile, residual-solvent data, or a sample for evaluation—state that requirement before purchase. This reduces the risk of assuming that a standard offer includes tests or documents that were never specified.
Compare quotations on more than unit price. Ask about available pack sizes, minimum order quantity, lead time, shipping conditions, and whether the quoted material is available for immediate shipment or subject to production or confirmation. These details can vary by lot, quantity, destination, and documentation needs, so they should be confirmed in the supplier’s written offer. For planning, treat an estimated lead time as provisional until the order and shipment details are confirmed.
Maison Chemical supports B2B inquiries for specialty chemicals and pharmaceutical intermediates, including evaluation of sourcing requirements for CAS 903550-26-5. We can discuss the quantity required, intended application, target specification, and documentation needed for your purchasing review. Availability, packaging, lead time, and lot-specific analytical information should be confirmed at the time of inquiry. We do not treat an unverified specification or estimated delivery detail as a guaranteed product attribute.
To help us respond efficiently, include your target quantity, destination country, required assay or impurity limits, and any documentation expectations. If the compound is being assessed for a defined reaction, you may also share relevant handling or process constraints without disclosing confidential route details. We can then review the request and clarify which supply and documentation options can be offered. Final suitability remains dependent on your own technical evaluation and acceptance criteria.
CAS 903550-26-5 is a THP-substituted pyrazole bearing a pinacol boronic ester at the 5-position, with a structure-derived molecular weight of approximately 278.16 g/mol. Its boronate group makes it a candidate building block for selected coupling strategies, while the N-THP substituent may influence route design and downstream processing. These structural features indicate potential use, not guaranteed reaction performance or a universal specification. Before buying, verify identity, lot-specific assay, relevant impurity data, handling guidance, and document availability.
If you are sourcing this compound, define your quantity and acceptance criteria first, then request a written quotation and lot-specific documents from Maison Chemical. This approach gives your procurement and technical teams a clear basis for evaluating both material fit and supply terms. Contact us with your requirements to discuss availability and a sourcing option for your project.
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